A wide variety of cancers involving the skin and soft tissues of the penis can occur, though cancer of the penis is not common (Mosconi et al., 2005). Any lesion on the penis must be examined by a physician, for benign and malignant conditions can be very similar in appearance, and STIs can appear as lesions. Even though most men handle and observe their penis daily, there is often significant delay between a person’s recognition of a lesion and seeking medical attention. Fear and embarrassment may contribute most to this problem, yet almost all of these lesions are treatable if caught early.